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38870-89-2 - Methoxyacetyl chloride, 97%, stab. with ca 0.3% magnesium oxide - L03210 - Alfa Aesar

L03210 Methoxyacetyl chloride, 97%, stab. with ca 0.3% magnesium oxide

CAS Number
38870-89-2
Synonyms

Size Price ($) Quantity Availability
5g 38.73
25g 117.42
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Methoxyacetyl chloride, 97%, stab. with ca 0.3% magnesium oxide

MDL
MFCD00000728
EINECS
254-169-2

Chemical Properties

Formula
CH3OCH2COCl
Formula Weight
108.52
Melting point
<-40°
Boiling Point
112-113°
Flash Point
28°(82°F)
Density
1.185
Refractive Index
1.4240
Sensitivity
Moisture Sensitive
Solubility
Miscible with acetone, ether, carbon tetrachloride and chloroform.

Applications

Methoxyacetyl chloride is used as an intermediate for active pharmaceutical ingredients and dyes. Further, it acts as a precursor for the synthesis of agrochemicals.

Notes

Moisture sensitive. Store in a cool place. Incompatible with water, alcohols, oxidizing agents and strong bases.

Literature References

Reagent for the chloromethylation of aromatics under Friedel-Crafts conditions, avoiding the use of chloromethyl methyl ether: Tetrahedron Lett., 24, 1933 (1983). For a study of the kinetics of chloromethylation of benzene and toluene in the presence of SnCl4, see: J. Org. Chem., 62, 2694 (1997). Compare Methoxyacetic acid, B22917.

Has also been used for the protection of alcohols as methoxyacetate esters, formed in the presence of pyridine, and cleaved using methanolic or aqueous ammonia ca. 20x faster than acetate: Tetrahedron Lett., 4273 (1968). Selective cleavage with Yb(OTf)3: J. Org. Chem., 61, 4491 (1996), or ethanolamine in IPA: J. Org. Chem., 60, 331 (1995), have also been reported.

Tiwari, D. K.; Pogula, J.; Tiwari, D. K. A general and practical route to 4,5-disubstituted oxazoles using acid chlorides and isocyanides. RSC Adv. 2015, 5 (65), 53111-53116.

Zadehahmadi, F.; Ahmadi, F.; Tangestaninejad, S.; Moghadam, M.; Mirkhani, V.; Mohammadpoor-Baltork, I.; Kardanpour, R. Catalytic CO2 fixation using tin porphyrin supported on organic and inorganic materials under mild conditions. J. Mol. Catal. A: Chem. 2015, 398, 1-10.

GHS Hazard and Precautionary Statements

Hazard Statements: H331-H314-H318-H226

Toxic if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapour.

Precautionary Statements: P280-P305+P351+P338-P309-P310

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician.

Other References

Beilstein
1740244
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2918.99
TSCA
No

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