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L03305 Thioacetic acid, 97%

CAS Number
507-09-5
Synonyms
Thiolacetic acid

Stock No. Size Price ($) Quantity Availability
L03305-14 25g 24.10
L03305-22 100g 40.10
L03305-36 500g 114.00
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Thioacetic acid, 97%

MDL
MFCD00004853
EINECS
208-063-8

Chemical Properties

Formula
C2H4OS
Formula Weight
76.12
Melting point
-17°
Boiling Point
97°
Flash Point
18°(64°F)
Density
1.068
Refractive Index
1.4640
Storage & Sensitivity
Keep Cold.
Solubility
Soluble in water. (27g/L) at 16°C.

Applications

Thioacetic acid is a reagent for introduction of the thiol group into organic molecules. It is used as flavor & Fragrance Intermediates. It is used to manufacture captopril(antihypertension) and spironolac-tone (diuretic).

Notes

Protect from heat. Store away from oxidizing agents. Incompatible with strong bases, strong oxidizing agents, metals.

Literature References

Wen Yang; Da-Ming Du. Squaramide-catalysed enantio- and diastereoselective sulfa-Michael addition of thioacetic acid to α,β-disubstituted nitroalkenes.Organic & Biomolecular Chemistry.2012, 10 (34), 6876-6884.

Libo Hu; Hui Zhu; Da-Ming Du; Jiaxi Xu. Efficient synthesis of taurine and structurally diverse substituted taurines from aziridines.Journal of Organic Chemistry.2007, 72 (12), 4543-4546.

Used in several different ways for the introduction of the thiol group: Radical addition to unactivated alkenes: J. Chem. Soc., 2123 (1951). Conjugate (Michael) addition to activated double bonds: J. Am. Chem. Soc., 77, 5144 (1955); 81, 1224 (1959). Nucleophilic displacement of halide, tosylate or acetate: J. Am. Chem. Soc., 73, 2659 (1951); Carbohydr. Res., 17, 457 (1971). Alcohols can be converted to thiol esters under Mitsunobu conditions, followed by LAH reduction to the thiol: Tetrahedron Lett., 3119 (1981).

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H301-H317-H318-H335

Highly flammable liquid and vapour. Toxic if swallowed. May cause an allergic skin reaction. Causes serious eye damage. May cause respiratory irritation.

Precautionary Statements: P210-P233-P240-P241-P242-P243-P261-P264b-P270-P272-P280-P301+P310-P303+P361+P353-P305+P351+P338-P310-P330-P333+P313-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation or rash occurs: Get medical advice/attention. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,9320
Beilstein
773684
Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2930.90
TSCA
Yes
RTECS
AJ5600000

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