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Thioacetic acid is a reagent for introduction of the thiol group into organic molecules. It is used as flavor & Fragrance Intermediates. It is used to manufacture captopril(antihypertension) and spironolac-tone (diuretic).
Wen Yang; Da-Ming Du. Squaramide-catalysed enantio- and diastereoselective sulfa-Michael addition of thioacetic acid to α,β-disubstituted nitroalkenes.Organic & Biomolecular Chemistry.2012, 10 (34), 6876-6884.
Libo Hu; Hui Zhu; Da-Ming Du; Jiaxi Xu. Efficient synthesis of taurine and structurally diverse substituted taurines from aziridines.Journal of Organic Chemistry.2007, 72 (12), 4543-4546.
Used in several different ways for the introduction of the thiol group: Radical addition to unactivated alkenes: J. Chem. Soc., 2123 (1951). Conjugate (Michael) addition to activated double bonds: J. Am. Chem. Soc., 77, 5144 (1955); 81, 1224 (1959). Nucleophilic displacement of halide, tosylate or acetate: J. Am. Chem. Soc., 73, 2659 (1951); Carbohydr. Res., 17, 457 (1971). Alcohols can be converted to thiol esters under Mitsunobu conditions, followed by LAH reduction to the thiol: Tetrahedron Lett., 3119 (1981).
Hazard Statements: H225-H302-H332-H314-H318-H317
Highly flammable liquid and vapour. Harmful if swallowed. Harmful if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. May cause an allergic skin reaction.
Precautionary Statements: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.