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N-Methylformamide is used to prepare methyl isocyanate. It is used as an extraction solvent for aromatic hydrocarbons and acts as a ligand in coordination chemistry. It is employed as a solvent in oil refineries and in aluminum electrolytic capacitors. Further, it is used as a reagent in organic synthesis. In addition to this, it is used as an investigational anticancer drug and an intermediate in the production of some pharmaceutical compounds.
Reagent for replacement of an activated chlorine in an aromatic or heteroaromatic ring by the methylamino group: Synthesis, 39 (1980).
Precursor of methyl isocyanide (highly toxic!), by dehydration with tosyl chloride in pyridine: Org. Synth. Coll., 5, 772 (1973).
Emets, V. V.; Damaskin, B. B. Two-dimensional pressure of chemisorbed dimethylformamide and N-methylformamide molecules at Ga-, (In-Ga)-, and (Tl-Ga)-electrodes. Russ. J. Electrochem. 2015, 51 (8), 789-795.
Bunkan, A. J. C.; Hetzler, J.; Mikoviny, T.; Wisthaler, A.; Nielsen, C. J.; Olzmann, M. The reactions of N-methylformamide and N,N-dimethylformamide with OH and their photo-oxidation under atmospheric conditions: experimental and theoretical studies. Phys. Chem. Chem. Phys. 2015, 17, 7046-7059.
Hazard Statements: H312-H360D
Harmful in contact with skin. May damage the unborn child.
Precautionary Statements: P201-P202-P281-P302+P352-P308+P313-P312-P363-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Use personal protective equipment as required. IF ON SKIN: Wash with plenty of soap and water. IF exposed or concerned: Get medical advice/attention. Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant