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Condensation with crotonaldehyde gives 2,4-dioxo-6-methylpyrido[3,2-d]pyrimidine: J. Chem. Soc. (C), 1745 (1967). An improved procedure has been used in synthesis of inhibitors of human thymidylate synthase: J. Med. Chem., 27, 1710 (1984), and of dihydrofolate reductases: J. Med. Chem., 39, 1836 (1996):/n
Review of the use of uracils as starting materials in heterocyclic synthesis: Adv. Heterocycl. Chem., 55, 130 (1992)./n
Hazard Statements: H302
Harmful if swallowed.
Precautionary Statements: P264b-P270-P301+P312-P330-P501c
Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/ container to an approved waste disposal plant