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1-(2-Pyridyl)piperazine may be employed as reagent for the determination of both aliphatic and aromatic isocyanates in air by reversed-phase HPLC. It may be employed as reagent for the fluorometric determination of airborne diisocyantes. It is a compound that belongs to a class of selective α2-adrenoceptor antagonists. 1-(2-Pyridyl)piperazine shows sympatholytic activity. 1-(2-Pyridyl)piperazine is also a metabolite of Azaperone.
P.A. Goldberg; R.F. Walker; P.A. Ellwood; H.L. Hardy. Determination of trace atmospheric isocyanate concentrations by reversed-phase high-performance liquid chromatography using 1-(2-pyridyl)piperazine reagent.Journal of Chromatography A.1981,212 93-104.
T. Salthammer; C. Wismach; H. Miertzsch. Absorption and fluorescence of 1-(2-pyridyl)-piperazine and four diisocyanate derivatives in solution.Journal of Photochemistry and Photobiology A: Chemistry.1997,107 159-164.
Hazard Statements: H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.