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6,9-Dichloro-2-methoxyacridine is used to prepare 6-chloro-2-methoxy-acridin-9-ylamine by reacting with phenol and ammonium carbonate. It is used in the preparation of 9-amino-6-chloro-2-methoxyacridine, N'-(6-Chloro-2-methoxy-acridin-9-yl)-heptylamine and N,N'-bis-(6-chloro-2-methoxy-acridin-9-yl)-hexane-1,6-diamine. Further, it is involved in the preparation of 4-aminoquinoline and 9-aminoacridine derivatives by reaction with quinolizidinylalkylamines.
Staderini, M.; Bolognesi, M. L.; Menéndez, J. C. Lewis Acid-Catalyzed Generation of C-C and C-N Bonds on pi-Deficient Heterocyclic Substrates. Adv. Synth. Catal. 2015, 357 (1), 185-195.
Wang, T.; Goodall, M. L.; Gonzales, P.; Sepulveda, M.; Martin, K. R.; Gately, S.; MacKeigan, J. P. Synthesis of Improved Lysomotropic Autophagy Inhibitors. J. Med. Chem. 2015, 58 (7), 3025-3035.
Hazard Statements: H315-H319-H334-H317-H335
Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. May cause respiratory irritation.
Precautionary Statements: P284-P261-P280a-P305+P351+P338-P405-P501a
Wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.