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86-38-4 - 6,9-Dichloro-2-methoxyacridine, 98% - 3,9-Dichloro-7-methoxyacridine - L05913 - Alfa Aesar

L05913 6,9-Dichloro-2-methoxyacridine, 98%

CAS Number
86-38-4
Synonyms
3,9-Dichloro-7-methoxyacridine

Size Price ($) Quantity Availability
5g 29.30
25g 92.40
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6,9-Dichloro-2-methoxyacridine, 98%

MDL
MFCD00005028
EINECS
201-666-7

Chemical Properties

Formula
C14H9Cl2NO
Formula Weight
278.14
Melting point
163-165°
Solubility
Insoluble in water.

Applications

6,9-Dichloro-2-methoxyacridine is used to prepare 6-chloro-2-methoxy-acridin-9-ylamine by reacting with phenol and ammonium carbonate. It is used in the preparation of 9-amino-6-chloro-2-methoxyacridine, N'-(6-Chloro-2-methoxy-acridin-9-yl)-heptylamine and N,N'-bis-(6-chloro-2-methoxy-acridin-9-yl)-hexane-1,6-diamine. Further, it is involved in the preparation of 4-aminoquinoline and 9-aminoacridine derivatives by reaction with quinolizidinylalkylamines.

Notes

Incompatible with oxidizing agents.

Literature References

Staderini, M.; Bolognesi, M. L.; Menéndez, J. C. Lewis Acid-Catalyzed Generation of C-C and C-N Bonds on pi-Deficient Heterocyclic Substrates. Adv. Synth. Catal. 2015, 357 (1), 185-195.

Wang, T.; Goodall, M. L.; Gonzales, P.; Sepulveda, M.; Martin, K. R.; Gately, S.; MacKeigan, J. P. Synthesis of Improved Lysomotropic Autophagy Inhibitors. J. Med. Chem. 2015, 58 (7), 3025-3035.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
226309
Harmonized Tariff Code
2933.79
TSCA
No

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