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L06051 2,4-Dichloro-6,7-dimethoxyquinazoline, 97%

CAS Number
27631-29-4
Synonyms

Stock No. Size Price ($) Quantity Availability
L06051-03 1g 22.40
L06051-06 5g 56.60
L06051-14 25g 197.00
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2,4-Dichloro-6,7-dimethoxyquinazoline, 97%

MDL
MFCD00051733
EINECS
000-000-0

Chemical Properties

Formula
C10H8Cl2N2O2
Formula Weight
259.09
Melting point
175-179°
Storage & Sensitivity
Moisture Sensitive. Store under Nitrogen. Ambient temperatures.
Solubility
Insoluble in water.

Applications

2,4-Dichloro-6,7-dimethoxyquinazoline is used as an intermediate in the preparation of potential inhibitors of epidermal growth factor receptor kinases. It is also used as an intermediate in the preparation of terazosin.

Notes

Moisture Sensitive. Incompatible with oxidizing agents. Store in a cool, dry conditions in well sealed container.

Literature References

T. H. Althuis; H. J. Hess. Synthesis and identification of the major metabolites of prazosin formed in dog and rat. J. Med. Chem.1977, 20, (1), 146-149.

Hans J. Hess; Timothy H. Cronin; Alexander Scriabine. Antihypertensive 2-amino-4(3H)-quinazolinones. J. Med. Chem.1968, 11, (1), 130-136.

For a review of the chemistry of quinazolines, see: Adv. Het. Chem., 24, 1 (1979).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
190331
Harmonized Tariff Code
2933.59
TSCA
No

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