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106-52-5 - 4-Hydroxy-1-methylpiperidine, 98% - 1-Methyl-4-piperidinol - L06415 - Alfa Aesar

L06415 4-Hydroxy-1-methylpiperidine, 98%

CAS Number
106-52-5
Synonyms
1-Methyl-4-piperidinol

Size Price ($) Quantity Availability
100g 38.70
500g 135.00
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4-Hydroxy-1-methylpiperidine, 98%

MDL
MFCD00006500
EINECS
203-406-8

Chemical Properties

Formula
C6H13NO
Formula Weight
115.18
Melting point
26-30°
Boiling Point
198-200°
Flash Point
87°(188°F)
Density
0.98
Refractive Index
1.4790
Sensitivity
Hygroscopic
Solubility
Soluble in water.

Applications

4-Hydroxy-1-methylpiperidine is used as reactant for optimization of Novobiocin scaffold to product antitumor agents, substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis. It is also used as a reactant in the synthesis of CaMKII, VEGFR and FGFR kinase inhibitors and Phosphoinositide-3-kinase, Protein lysine methyltransferase G9a inhibitors.

Notes

Hygroscopic. Store under dry inert gas. Store away from moisture and oxidizing agents. Incompatible with water and oxidizing agents. Store at 4°C.

Literature References

Z. Dega-Szafran; E. Dulewicz; G. Dutkiewicz; Z. Kosturkiewicz; M. Szafran. Two polymorphs of 4-hydroxy-1-methylpiperidine betaine hydrochloride studied by X-ray and DFT methods.Journal of Molecular Structure.2005,751 139-150.

Z. Dega-Szafran; G. Dutkiewicz; Z. Fojud, Z. Kosturkiewicz; M. Szafran. Ring inversion in 4-hydroxy-1-methylpiperidine betaine studied by X-ray, FTIR, 13C CP MAS NMR and DFT calculations.Journal of Molecular Structure.2009,917 76-83.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
103024
Harmonized Tariff Code
2933.39
TSCA
Yes

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