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Carbonyl cyanide 3-chlorophenylhydrazone is a widely used uncoupler of oxidative phosphorylation.
A.J.Verhoeven; B.P.Neve; H.Jansen. Secretion and apparent activation of human hepatic lipase requires proper oligosaccharide processing in the endoplasmic reticulum. Biochemical Journal. 1999, 337,(Pt 1), 133-140.
G.Biswas; O.A.Adebanjo; B.D.Freedman; H.K.Anandatheerthavarada; C.Vijayasarathy; M.Zaidi; M.Kotlikoff; N.G.Avadhani. Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk. EMBO Journal. 1999, 18,(3), 522-533.
Uncoupler of oxidative phosphorylation: Biochem. Biophys. Acta, 394 145 (1975); Biochemistry, 17, 2245 (1978).
Hazard Statements: H301-H315-H319-H335
Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P301+P310a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.