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677-43-0 - N,N-Dimethylphosphoramidodichloridate, 97% - Dimethylaminophosphoryl dichloride - N,N-Dimethylphosphoramic dichloride - L07231 - Alfa Aesar

L07231 N,N-Dimethylphosphoramidodichloridate, 97%

CAS Number
677-43-0
Synonyms
Dimethylaminophosphoryl dichloride
N,N-Dimethylphosphoramic dichloride

Size Price ($) Quantity Availability
5g 45.90
25g 145.00
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N,N-Dimethylphosphoramidodichloridate, 97%

MDL
MFCD00013896
EINECS
211-641-2

Chemical Properties

Formula
C2H6Cl2NOP
Formula Weight
161.96
Boiling Point
89-90°/20mm
Flash Point
>110°(230°F)
Density
1.360
Refractive Index
1.4630
Sensitivity
Moisture Sensitive
Solubility
Miscible with dimethoxyethane.

Applications

N,N-Dimethylphosphoramidodichloridate is used in the synthesis of phosphoramidates as well as (RS)-ethyl N,N-dimethylphosphoramidocyanidate (Nerve agent GA) which is used as a chemical weapon. It forms active intermediates, which react with alcohols in situ to give esters. It is also used to convert primary alcohols to alkyl chlorides. Furthe, it serves as an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. In addition to this, it reacts with 1,2 diols to prepare cyclic phosphoric amides followed by alkenes after reduction.

Notes

Moisture and air sensitive. Hygroscopic. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Literature References

With 1,2-diols forms cyclic phosphoric amides which can be reduced to alkenes, e.g. with Na in xylene: Synth. Commun., 5, 293 (1975).

In the presence of pyridine, carboxylic acids form active intermediates which react with alcohols in situ to give esters: Tetrahedron Lett., 4461 (1978). Has also been used to convert primary alcohols to alkyl chlorides: Chem. Lett., 923 (1978).

Wils, E. R. Mass spectral data of precursors of chemical warfare agents. Fresenius J. Anal. Chem. 1990, 338 (1), 22-27.

Santilli, A. A.; Morris, R. L.; Scotese, A. C.; Strike, D. P. A convenient synthesis of N-[2-[[[5-[(dimethlamino methyl]-2-furanylmethyl]thio]ethyl]thieno-[3, 4-d]isothiazol-3-amine-1,1-dioxide hydrochloride,a potent gastric acid antisecretory agent. Org. Prep. Proced. Int. 1990, 22 (1), 71-76.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
969956
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2931.39
TSCA
No
RTECS
TB4025000

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