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5466-84-2 - 4-Nitrophthalic anhydride, tech. 90% - L08020 - Alfa Aesar

L08020 4-Nitrophthalic anhydride, tech. 90%

CAS Number
5466-84-2
Synonyms

Size Price ($) Quantity Availability
5g 59.60
25g 222.00
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4-Nitrophthalic anhydride, tech. 90%

MDL
MFCD00005922
EINECS
226-776-2

Chemical Properties

Formula
C8H3NO5
Formula Weight
193.11
Melting point
116-121°
Sensitivity
Moisture Sensitive
Solubility
Hydrolyzes in water.

Applications

4-Nitrophthalic anhydride is used an an intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472).

Notes

Moisture Sensitive. Store away from strong bases and oxidizing agents. Incompatible with water, bases, strong acids and oxidizing agents.

Literature References

R. L. Markezich; O. S. Zamek; P. E. Donahue; F. J. Williams. Reactions of 4-nitrophthalic anhydride with potassium fluoride and potassium nitrite.J. Org. Chem.1977, 42 (21), 3435-3436.

Ellis K. Fields; Seymour Meyerson. Reactions of 4-nitrophthalic anhydride.Tetrahedron Letters.1971, 12 719-722.

Reagent for the protection of primary amines as the corresponding phthalimides. Cleavage can be carried out with methylhydrazine: Synlett, 63 (1994).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P260-P201-P280g-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
179682
Harmonized Tariff Code
2917.39
TSCA
Yes
RTECS
TI3328000

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