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Attempts to lithiate aromatic dimethylamides tend to give ketones by displacement of the dimethylamino group. For lithiation of the diethyl- or diisopropylamides with subsequent alkylation or reaction with carbonyl compounds to give lactones, see: J. Org. Chem., 42, 1823 (1977):/n
For a review of the direct lithiation of aromatic tert-amides, see: Acc. Chem. Res., 15, 306 (1982)./n
Hazard Statements: H302-H312-H315-H319-H335
Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.