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L-Norvaline enhances NO production from activated macrophages. It is known to promote tissue regeneration and muscle growth and become a precursor in the penicillin biosynthetic pathway. It also can be used for nutrition agent and drug synthesis. For example: it can react with phthalic acid anhydride to get N,N-phthaloyl-L-norvaline.
Chiung-I Chang, et al. Macrophage Arginase Promotes Tumor Cell Growth and Suppresses Nitric Oxide-mediated Tumor Cytotoxicity.Cancer Res.,2001,611100-1106.
Xiu-Fen Ming, et al. Thrombin Stimulates Human Endothelial Arginase Enzymatic Activity via RhoA/ROCK Pathway Implications for Atherosclerotic Endothelial Dysfunction.Circulation.,2004,1103708-3714.