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L08750 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride, 98%

CAS Number
4568-71-2
Synonyms

Stock No. Size Price ($) Quantity Availability
L08750-14 25g 43.50
L08750-22 100g 134.00
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3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride, 98%

MDL
MFCD00011959
EINECS
224-947-6

Chemical Properties

Formula
C13H16ClNOS
Formula Weight
269.80
Melting point
142-145°
Storage & Sensitivity
Hygroscopic. Ambient temperatures.
Solubility
Soluble in water.

Applications

3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride, aliphatic aldehydes undergo the acyloin condensation in the presence of this catalyst and mild base. It acts as a catalyst for the addition of aliphatic and heterocyclic aldehydes to α,β-unsaturated ketones, nitriles and esters.

Notes

Hygroscopic. Store away from water and oxidizing agents. Protect from humidity and water. Incompatible with strong oxidizing agents.

Literature References

Aliphatic aldehydes undergo the acyloin condensation in the presence of this catalyst and mild base. For example (butyraldehyde to butyroin), see: Org. Synth. Coll., 7, 95 (1990).

The same system is effective in catalyzing the addition of aldehydes to electron-deficient alkenes, including ɑß-unsaturated ketones, esters and nitriles (Stetter reaction), providing a non-toxic alternative to cyanide in these reactions; e.g. in the synthesis of dihydrojasmone: Org. Synth. Coll., 8, 620 (1993):

For reviews, see: Angew. Chem. Int. Ed., 15, 639 (1976); Org. React., 40, 407 (1991). For a further example, see Phenyl­ vinyl­ sulfone, A14794.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
3788921
Harmonized Tariff Code
2934.10
TSCA
No

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