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It is employed as an antiepileptic drug. It is hydrolyzed quickly to VPA in vivo, but has intrinsic anticonvulsant activity. Also a reactant used in the synthesis of mutual prodrugs containing bio-cleavable and drug releasable disulfide linkers.
Ilan Winkler; Simcha Blotnik; Jakob Shimshoni; Boris Yagen; Marshall Devor; Meir Bialer. Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain. British Journal of Pharmacology. 2005, 146 (2), 198-208.
Galit Shaltiel et. al. Valproate decreases inositol biosynthesis. Biological Psychiatry. 2004, 56(11), 868-874.
Hazard Statements: H302
Harmful if swallowed.
Precautionary Statements: P264-P270-P301+P312a-P330-P501a
Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.