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3222-47-7 - 6-Methylnicotinic acid, 99% - 6-Methylpyridine-3-carboxylic acid - L08877 - Alfa Aesar

L08877 6-Methylnicotinic acid, 99%

CAS Number
3222-47-7
Synonyms
6-Methylpyridine-3-carboxylic acid

Size Price ($) Quantity Availability
1g 34.10
5g 101.00
25g 402.00
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6-Methylnicotinic acid, 99%

MDL
MFCD00006341
EINECS
000-000-0

Chemical Properties

Formula
C7H7NO2
Formula Weight
137.14
Melting point
210-215°
Solubility
Sparingly soluble in water.

Applications

6-Methylnicotinic acid is an intermediate of the drug etoricoxib (a non- steroidal anti-inflammatory drug for the treatment of arthritis and osteoarthritis). It is also used as organic intermediates.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents. Store away from oxidizing agents.

Literature References

Andreas Tinschert; Andreas Kiener; Klaus Heinzmann; A. Tschech. Isolation of new 6-methylnicotinic-acid-degrading bacteria, one of which catalyses the regioselective hydroxylation of nicotinic acid at position C2.Archives of Microbiology.1997, 168 355-361.

B.-M. Kukovec; Z. Popovic and G. Pavlovic. A new coordination mode of 6-methyl­nicotinic acid in trans-tetra­aquabis­(6-methyl­pyridine-3-carboxyl­ato-[kappa]O)cobalt(II) tetra­hydrate.Acta Cryst.2007, C63 m615-m617.

Dilithiation can be effected with LDA, allowing substitution at the 6-methyl group, as, for example carboxylation in the synthesis of methotrexate analogues: J. Med. Chem., 40, 370 (1997).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
112049
Harmonized Tariff Code
2933.39
TSCA
No

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