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56-92-8 - Histamine dihydrochloride, 98+% - L09198 - Alfa Aesar

L09198 Histamine dihydrochloride, 98+%

CAS Number
56-92-8
Synonyms

Size Price ($) Quantity Availability
5g 39.80
25g 134.00
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Histamine dihydrochloride, 98+%

MDL
MFCD00012703
EINECS
200-298-4

Chemical Properties

Formula
C5H9N3•2HCl
Formula Weight
184.07
Melting point
245-249°
Solubility
Very soluble in water and methanol. Soluble in ethanol.

Applications

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents. Store away from oxidizing agents. Store at 4°C.

Literature References

Egla Yareth Bivián-Castro; Mercedes G López; Mario Pedraza-Reyes; Sylvain Bernès; Guillermo Mendoza-Díaz. Synthesis, characterization, and biological activity studies of copper(II) mixed compound with histamine and nalidixic acid.Bioinorganic Chemistry and Applications.2009, 603651.

Anna Martnera; Fredrik B Thoréna; Johan Aureliusa; Jonas Söderholma; Mats Brunea & Kristoffer Hellstrand. Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia.Expert Review of Hematology.2010, 3 381-391.

GHS Hazard and Precautionary Statements

Hazard Statements: H334-H315-H319-H317-H335

May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause respiratory irritation.

Precautionary Statements: P285-P261-P280-P305+P351+P338-P304+P340-P342+P311-P362-P312-P405-P501a

In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,4719
Beilstein
3624116
Harmonized Tariff Code
2933.29
TSCA
Yes
RTECS
MS1575000

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