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Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist.
Egla Yareth Bivián-Castro; Mercedes G López; Mario Pedraza-Reyes; Sylvain Bernès; Guillermo Mendoza-Díaz. Synthesis, characterization, and biological activity studies of copper(II) mixed compound with histamine and nalidixic acid.Bioinorganic Chemistry and Applications.2009, 603651.
Anna Martnera; Fredrik B Thoréna; Johan Aureliusa; Jonas Söderholma; Mats Brunea & Kristoffer Hellstrand. Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia.Expert Review of Hematology.2010, 3 381-391.
Hazard Statements: H315-H317-H319-H334-H335
Causes skin irritation. May cause an allergic skin reaction. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P272-P280-P285-P302+P352-P304+P340-P305+P351+P338-P333+P313-P337+P313-P342+P311-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. In case of inadequate ventilation wear respiratory protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If skin irritation or rash occurs: Get medical advice/attention. If eye irritation persists: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant