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2-Thiopheneacetyl chloride was used in the synthesis of (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator, 5-fluorouracil-cephalosporin prodrug, series of new N,N?-di(thiopheneacetyl)diamines derivatives and 6-β-(thiophen-2?-yl)acetamidomorphine. Also used in the synthesis of Nitrocefin.
Moher ED, et al. Development of an efficient synthesis for a nipecotate-containing immunopotentiator. Org. Process Res. Dev,2004, 8 (4), 593-6.
Ryan M Phelan; Marc Ostermeier; Craig A Townsend; Ryan M. Phelan; Marc Ostermeier; Craig A. Townsend. Design and synthesis of a beta-lactamase activated 5-fluorouracil prodrug. Bioorganic & Medicinal Chemistry Letters,2009, 19(4), 1261-1263.
Hazard Statements: H302-H314-H318
Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.