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L09329 Triethyl 2-phosphonobutyrate, 97%

CAS Number
Diethyl 1-(ethoxycarbonyl)propanephosphonate
2-Phosphonobutyric acid triethyl ester

Stock No. Size Price ($) Quantity Availability
L09329-06 5g 33.20
L09329-14 25g 118.00
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Triethyl 2-phosphonobutyrate, 97%


Chemical Properties

Formula Weight
Boiling Point
Flash Point
Refractive Index
Storage & Sensitivity
Ambient temperatures.
Not miscible or difficult to mix with water.


Reactant used for preparation of furospinosulin-1 and analogs as hypoxia-selective antitumor agents, Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer?s drugs, phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents, PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists, notch-sparing γ-secretase inhibitors derived from PPAR agonist library and plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis.


Store in cool. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literature References

Yuan Cheng et. al. From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).. Journal of medicinal and pharmaceutical chemistry,2011, 54 (16), 5836-5857.

Shintaro Ban et. al. Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists. Bioorganic & Medicinal Chemistry,2011, 19(10), 3183-3191.

Intermediate for Wadsworth-Emmons formation of ɑ-ethylacrylic esters. See Appendix 1.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code


  • A13200

    2,4-Hexadienal, predominantly trans,trans, 95%
  • A17881

    Isobutyltriphenylphosphonium bromide, 98+%
  • 11475

    Molybdenum rod, 5mm (0.2in) dia, Puratronic®, 99.97% (metals basis)
  • H53439

    3-Methyl-1-butyne, 96%

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