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L09527 Chloromethyl chloroformate, 97%

CAS Number
22128-62-7
Synonyms
Chloroformic acid chloromethyl ester

Stock No. Size Price ($) Quantity Availability
L09527-09 10g 69.00
L09527-18 50g 254.00
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Chloromethyl chloroformate, 97%

MDL
MFCD00077688
EINECS
244-793-3

Chemical Properties

Formula
C2H2Cl2O2
Formula Weight
128.94
Melting point
<-20°
Boiling Point
107-108°
Flash Point
95°(203°F)
Density
1.465
Refractive Index
1.4295
Storage & Sensitivity
Keep Cold. Moisture Sensitive.
Solubility
Slightly miscible with water.

Applications

Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.

Notes

Incompatible with oxidizing agents and water.

Literature References

Naganathan, S.; Andersen, D. L.; Andersen, N. G.; Lau, S.; Lohse, A.; Sorensen, M. D. Process Development and Scale-Up of a Benzoxazepine-Containing Kinase Inhibitor. Org. Process Res. Dev. 2015, 19 (7), 721-734.

Wu, P.; Petersen, M. A.; Cohrt, A. E.; Petersen, R.; Clausen, M. H.; Nielsen, T. E. Reductive Cyclization and Petasis-Like Reaction for the Synthesis of Functionalized γ-Lactams. Eur. J. Org. Chem. 2015, 2015 (11), 2346-2350.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H314-H330-H335

Harmful if swallowed. Causes severe skin burns and eye damage. Fatal if inhaled. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P270-P271-P280-P284-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. Wear respiratory protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
506426
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2915.90
TSCA
No

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