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Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.
Naganathan, S.; Andersen, D. L.; Andersen, N. G.; Lau, S.; Lohse, A.; Sorensen, M. D. Process Development and Scale-Up of a Benzoxazepine-Containing Kinase Inhibitor. Org. Process Res. Dev. 2015, 19 (7), 721-734.
Wu, P.; Petersen, M. A.; Cohrt, A. E.; Petersen, R.; Clausen, M. H.; Nielsen, T. E. Reductive Cyclization and Petasis-Like Reaction for the Synthesis of Functionalized γ-Lactams. Eur. J. Org. Chem. 2015, 2015 (11), 2346-2350.
Hazard Statements: H302-H331-H314-H318
Harmful if swallowed. Toxic if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P280-P232-P305+P351+P338-P309-P310a-P402
Wear protective gloves/protective clothing/eye protection/face protection. Protect from moisture. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Store in a dry place.