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22128-62-7 - Chloromethyl chloroformate, 97% - Chloroformic acid chloromethyl ester - L09527 - Alfa Aesar

L09527 Chloromethyl chloroformate, 97%

CAS Number
22128-62-7
Synonyms
Chloroformic acid chloromethyl ester

Size Price ($) Quantity Availability
10g 64.40
50g 237.00
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Chloromethyl chloroformate, 97%

MDL
MFCD00077688
EINECS
244-793-3

Chemical Properties

Formula
C2H2Cl2O2
Formula Weight
128.94
Melting point
<-20°
Boiling Point
107-108°
Flash Point
95°(203°F)
Density
1.465
Refractive Index
1.4295
Sensitivity
Moisture Sensitive
Solubility
Slightly miscible with water.

Applications

Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.

Notes

Incompatible with oxidizing agents and water.

Literature References

Naganathan, S.; Andersen, D. L.; Andersen, N. G.; Lau, S.; Lohse, A.; Sorensen, M. D. Process Development and Scale-Up of a Benzoxazepine-Containing Kinase Inhibitor. Org. Process Res. Dev. 2015, 19 (7), 721-734.

Wu, P.; Petersen, M. A.; Cohrt, A. E.; Petersen, R.; Clausen, M. H.; Nielsen, T. E. Reductive Cyclization and Petasis-Like Reaction for the Synthesis of Functionalized γ-Lactams. Eur. J. Org. Chem. 2015, 2015 (11), 2346-2350.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H331-H314-H318

Harmful if swallowed. Toxic if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P280-P232-P305+P351+P338-P309-P310a-P402

Wear protective gloves/protective clothing/eye protection/face protection. Protect from moisture. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER/doctor Store in a dry place.

Other References

Beilstein
506426
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2915.90
TSCA
No

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