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L09553 2-Bromo-5-fluorobenzyl bromide, 97%

CAS Number
112399-50-5
Synonyms

Stock No. Size Price ($) Quantity Availability
L09553-03 1g 69.70
L09553-06 5g 222.00
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2-Bromo-5-fluorobenzyl bromide, 97%

MDL
MFCD00042187

Chemical Properties

Formula
C7H5Br2F
Formula Weight
267.92
Melting point
33-36°
Boiling Point
89-90°/1mm
Refractive Index
1.5900
Storage & Sensitivity
Ambient temperatures.
Solubility
Difficult to mix in water.

Applications

It is an important pharmaceutical intermediate. Alkylation of the β-amino ester 1a with 2-bromo-5-fluorobenzyl bromide yields Benzazepines as a white solid after silica gel chromatography.

Notes

Store in cool dry condition. Incompatible with strong oxidizing agents. Ensure ventilation. Protect from electrostatic charges.

Literature References

Valérie Declerck.; Patrice Ribière.; Yannig Nédellec.; Hassan Allouchi.; Jean Martinez.; Frédéric Lamaty. A Microwave-Assisted Heck Reaction in Poly(ethylene glycol) for the Synthesis of Benzazepines.European Journal of Organic Chemistry. 2007, 2007 (1),201-208 .

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H335

Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
4177658
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2903.99
TSCA
No

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