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(1R,2R)-(+)-1,2-Diphenyl-1,2-ethanediamine is used as chiral solvation agent for determination of enantiomeric excess of chiral acids by NMR. It is used in various catalyst systems for asymmetric reactions.
François Touchard; Patrick Gamez; Fabienne Fache; Marc Lemaire. Chiral thiourea as ligand for the asymmetric reduction of prochiral ketones. Chiral thiourea as ligand for the asymmetric reduction of prochiral ketones.Tetrahedron Letters.1997, 38 2275-2278.
Chiral solvation agent for determination of enantiomeric excess of chiral acids by NMR.
In combination with various Lewis acids, forms a number of catalyst systems for asymmetric reactions including Diels-Alder, allylation and aldol reactions: Angew. Chem. Int. Ed., 30, 455 (1991). For use in enantioselective catalytic Diels-Alder reactions, see: J. Am. Chem. Soc., 111, 5493 (1989); Org. Synth. Coll., 9, 67 (1998).
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant