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16588-74-2 - 3,5-Bis(trifluoromethyl)phenyl isocyanate, 98% - L09582 - Alfa Aesar

L09582 3,5-Bis(trifluoromethyl)phenyl isocyanate, 98%

CAS Number
16588-74-2
Synonyms

Size Price ($) Quantity Availability
1g 31.40
5g 107.00
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3,5-Bis(trifluoromethyl)phenyl isocyanate, 98%

MDL
MFCD00013559

Chemical Properties

Formula
C9H3F6NO
Formula Weight
255.12
Boiling Point
62°/2mm
Flash Point
67°(152°F)
Density
1.476
Refractive Index
1.4300
Sensitivity
Moisture Sensitive
Solubility
Hydrolyzes with water.

Applications

3,5-Bis(trifluoromethyl)phenyl isocyanate is used in Chemical derivatization of amino-functionalized model surfaces. Preparation of arylaminothiocarbonylpyridinium zwitterionic salts, via an exothermic reaction with 4-pyrrolidinopyridine. Synthesis of (S)-3-hydroxymethyl-2-methoxymethoxy-2?-(3-(3,5-bis(trifluoromethyl)phenyl)uryl-benzyl)-1,10-binaphthalene. Synthesis of 1-[3,5-bis(trifluoromethyl) phenyl]-3-(2-pyridyl)thiourea, via reaction with 2-amino pyridine in MeCN.

Notes

Moisture Sensitive. Protect from heat. Store away from heat and oxidizing agents. Store under dry inert gas. Protect from humidity and water. Incompatible with heat, amines, alcohols and oxidizing agents.

Literature References

Nora Graf; Andreas Lippitz; Thomas Gross; Falko Pippig; Andreas Holländer; Wolfgang E S Unger. Determination of accessible amino groups on surfaces by chemical derivatization with 3,5-bis(trifluoromethyl)phenyl isothiocyanate and XPS/NEXAFS analysis.Analytical and Bioanalytical Chemistry.2010, 396 (2), 725-738.

Kazuaki Ishihara; Masatoshi Niwa; Yuji Kosugi. Zwitterionic salts as mild organocatalysts for transesterification.Organic Letters.2008, 10 (11), 2187-2190.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H302-H331-H315-H319-H334-H335

Combustible liquid. Harmful if swallowed. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.

Precautionary Statements: P260-P201-P280h-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
542272
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2929.10
TSCA
No

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