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5272-36-6 - 3-(Trimethylsilyl)propargyl alcohol, 98+% - 3-(Trimethylsilyl)-2-propyn-1-ol - L09649 - Alfa Aesar

L09649 3-(Trimethylsilyl)propargyl alcohol, 98+%

CAS Number
5272-36-6
Synonyms
3-(Trimethylsilyl)-2-propyn-1-ol

Size Price ($) Quantity Availability
1g 29.60
5g 81.60
25g 313.00
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3-(Trimethylsilyl)propargyl alcohol, 98+%

MDL
MFCD00002913
EINECS
226-094-5

Chemical Properties

Formula
C6H12OSi
Formula Weight
128.25
Boiling Point
170-172°
Flash Point
66°(150°F)
Density
0.865
Refractive Index
1.4510
Sensitivity
Moisture Sensitive
Solubility
Not miscible with water.

Applications

3-(Trimethylsilyl)propargyl alcohol is used as a reagent to synthesize Isbogrel, a Thromboxane A 2 (TXA 2) synthase inhibitor and also a TXA 2 receptor antagonist that has potential to treat asthma.

Notes

Moisture Sensitive. Store away from moisture and oxidizing agents. Protect from heat. Store under dry inert gas. Protect from humidity and water. Incompatible with oxidizing agents, heat and moisture.

Literature References

Reduction with Sodium bis(2-methoxyethoxy)­aluminum hydride, A13292, gives stereoselectively (E)-3-TMS-2-propen-1-ol: Org. Synth. Coll., 7, 524 (1990). For titanocene dichloride-promoted hydromagnesiation reaction with isobutylmagnesium bromide, see: Org. Synth. Coll., 8, 507, (1993). See Bis(cyclopentadienyl)­titanium dichloride, A11456.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H301-H315-H319-H335

Combustible liquid. Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280h-P305+P351+P338-P309-P310a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell:

Other References

Beilstein
1902505
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2931.90
TSCA
Yes

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