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Tetramethylammonium hydroxide pentahydrate is used in analytical chemistry as an ion pairing agent and a polarographic reagent. It finds application in gas chromatography/mass spectrometry (GC/MS), capillary isotachophoresis and capillary zone electrophoresis and liquid chromatography. Furthermore, it is utilized in the preparation of iron oxide nanoparticles which are useful as magnetic resonance imaging contrast agents and tetramethylammonium dithiocarboxylates. It acts as a developer or an etchant in semiconductor and photoelectric industries.
Engel, T.; Kickelbick, G. Furan-Modified Spherosilicates as Building Blocks for Self-Healing Materials. Eur. J. Inorg. Chem. 2015, 2015 (7), 1226-1232.
Azcarate, S. M.; Savio, M.; Smichowski, P.; Martinez, L. D.; Camira, J. M.; Gil, R. A. Single-step solubilization of milk samples with N,N-dimethylformamide for inductively coupled plasma-mass spectrometry analysis and classification based on their elemental composition. Talanta 2015, 143, 64-70.
Hazard Statements: H300-H311-H314-H318-H370-H372
Fatal if swallowed. Toxic in contact with skin. Causes severe skin burns and eye damage. Causes serious eye damage. Causes damage to organs. Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements: P260u-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
IF SWALLOWED: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.