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Tetramethylammonium hydroxide pentahydrate is used in analytical chemistry as an ion pairing agent and a polarographic reagent. It finds application in gas chromatography/mass spectrometry (GC/MS), capillary isotachophoresis and capillary zone electrophoresis and liquid chromatography. Furthermore, it is utilized in the preparation of iron oxide nanoparticles which are useful as magnetic resonance imaging contrast agents and tetramethylammonium dithiocarboxylates. It acts as a developer or an etchant in semiconductor and photoelectric industries.
Engel, T.; Kickelbick, G. Furan-Modified Spherosilicates as Building Blocks for Self-Healing Materials. Eur. J. Inorg. Chem. 2015, 2015 (7), 1226-1232.
Azcarate, S. M.; Savio, M.; Smichowski, P.; Martinez, L. D.; Camira, J. M.; Gil, R. A. Single-step solubilization of milk samples with N,N-dimethylformamide for inductively coupled plasma-mass spectrometry analysis and classification based on their elemental composition. Talanta 2015, 143, 64-70.
Hazard Statements: H300-H310-H314-H335-H370-H372
Fatal if swallowed. Fatal in contact with skin. Causes severe skin burns and eye damage. May cause respiratory irritation. Causes damage to organs. Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements: P260-P262-P264b-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Do not get in eyes, on skin, or on clothing. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant