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17176-77-1 - Dibenzyl phosphite, 90+% - Phosphorous acid dibenzyl ester - Dibenzylphosphonate - L09858 - Alfa Aesar

L09858 Dibenzyl phosphite, 90+%

CAS Number
17176-77-1
Synonyms
Phosphorous acid dibenzyl ester
Dibenzylphosphonate

Size Price ($) Quantity Availability
5g 28.75
25g 97.03
100g 245.14
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Dibenzyl phosphite, 90+%

MDL
MFCD00004774
EINECS
241-226-1

Chemical Properties

Formula
C14H15O3P
Formula Weight
262.25
Boiling Point
110-120°/0.1mm
Flash Point
>110°(230°F)
Density
1.187
Refractive Index
1.5540
Sensitivity
Moisture Sensitive
Solubility
Soluble in DMSO, Methanol. Reacts with water.

Applications

Dibenzyl phosphite is used for the phosphorylation of phenols involves reaction in the presence of N-ethyldiisopropylamine and DMAP to give the dibenzyl phenyl phosphate. It is used in the preparation of phenylalkylphosphonamidates which are then used as probes for a hydrophobic binding register in prostate-specific membrane antigen.

Notes

Store at 4°C. Moisture Sensitive. Incompatible with moisture and oxidizing agents. Store under dry inert gas. Store away from oxidizing agents.

Literature References

Lee J. Silverberg; John L. Dillon; Purushotham Vemishetti. A simple, rapid and efficient protocol for the selective phosphorylation of phenols with dibenzyl phosphite.Tetrahedron Letters.1996, 37 771-774.

Yu-Pei Cheng; Hui-Ting Chen; Chun-Cheng Lin. A convenient and highly stereoselective approach for α-galactosylation performed by galactopyranosyl dibenzyl phosphite with remote participating groups.Tetrahedron Letters.2002, 43 7721-7723.

A selective method for the phosphorylation of phenols involves reaction in the presence of N-ethyldiisopropylamine and DMAP to give the dibenzyl phenyl phosphate: Tetrahedron Lett., 37, 771 (1996).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H317

Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction.

Precautionary Statements: P261-P280-P305+P351+P338-P362-P363-P321-P332+P313-P333+P313-P337+P313-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Wash contaminated clothing before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If skin irritation or rash occurs: If eye irritation persists: Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,3014
Beilstein
1982794
Harmonized Tariff Code
2920.90
TSCA
No

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