L09970 Thiazole, 99%
SDS
| Stock No. | Size | Price ($) | Quantity | Availability |
|---|---|---|---|---|
| L09970-03 | 1g | 34.30 |
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| L09970-06 | 5g | 111.00 |
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| L09970-14 | 25g | 370.00 |
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Thiazole, 99%
Chemical Properties
Applications
Thiazole is used as a flavoring agent and in the preparation of dyes and rubber accelerators. It serves as a component of the vitamin thiamine (B1). It acts as a protected formyl group used in natural product synthesis. It reacts with alkyl lithium and Grignards reagent to prepare organometallic complexes. It is involved in the electrophilic aromatic substitution and nucleophilic aromatic substitution at C-5 and C-2 positions respectively. Further, it undergoes alkylation reaction to get thiazolium cation, which is used as a catalyst in the Stetter reaction and the Benzoin condensation. In addition to this, it is involved in the preparation of alagebrium.
Notes
Literature References
For an example of 2-lithiation, see: J. Med. Chem., 37, 3492 (1994). For other uses of 2-lithiothiazole, see 2-Bromothiazole, A14838.
Li, F.; Meng, F.; Wang, Y.; Zhu, C.; Cheng, Y. Polymer-based fluorescence sensor incorporating thiazole moiety for direct and visual detection of Hg2+ and Ag+. Tetrahedron 2015, 71 (11), 1700-1704.
Mallia, C. J.; Englert, L.; Walter, G. C.; Baxendale, I. R. Thiazole formation through a modified Gewald reaction. Beilstein J. Org. Chem. 2015, 11, 875-883.
GHS Hazard and Precautionary Statements
Hazard Statements: H226-H302
Flammable liquid and vapour. Harmful if swallowed.
Precautionary Statements: P210-P233-P240-P241-P242-P243-P264b-P270-P280-P301+P312-P303+P361+P353-P330-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Rinse mouth. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant
Other References
Chemicals
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Metals & Materials
Catalysts
