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L09970 Thiazole, 99%

CAS Number
288-47-1
Synonyms

Stock No. Size Price ($) Quantity Availability
L09970-03 1g 34.30
L09970-06 5g 111.00
L09970-14 25g 370.00
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Thiazole, 99%

MDL
MFCD00005315
EINECS
206-021-3

Chemical Properties

Formula
C3H3NS
Formula Weight
85.13
Melting point
-33°
Boiling Point
117-118°
Flash Point
22°(71°F)
Density
1.200
Refractive Index
1.5390
Storage & Sensitivity
Air Sensitive. Light Sensitive. Store under Nitrogen. Ambient temperatures.
Solubility
Soluble in ethanol and ether. Slightly soluble in water.

Applications

Thiazole is used as a flavoring agent and in the preparation of dyes and rubber accelerators. It serves as a component of the vitamin thiamine (B1). It acts as a protected formyl group used in natural product synthesis. It reacts with alkyl lithium and Grignard’s reagent to prepare organometallic complexes. It is involved in the electrophilic aromatic substitution and nucleophilic aromatic substitution at C-5 and C-2 positions respectively. Further, it undergoes alkylation reaction to get thiazolium cation, which is used as a catalyst in the Stetter reaction and the Benzoin condensation. In addition to this, it is involved in the preparation of alagebrium.

Notes

Air and light sensitive. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents and carbon dioxide.

Literature References

For an example of 2-lithiation, see: J. Med. Chem., 37, 3492 (1994). For other uses of 2-lithiothiazole, see 2-Bromothiazole, A14838.

Li, F.; Meng, F.; Wang, Y.; Zhu, C.; Cheng, Y. Polymer-based fluorescence sensor incorporating thiazole moiety for direct and visual detection of Hg2+ and Ag+. Tetrahedron 2015, 71 (11), 1700-1704.

Mallia, C. J.; Englert, L.; Walter, G. C.; Baxendale, I. R. Thiazole formation through a modified Gewald reaction. Beilstein J. Org. Chem. 2015, 11, 875-883.

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H302

Flammable liquid and vapour. Harmful if swallowed.

Precautionary Statements: P210-P233-P240-P241-P242-P243-P264b-P270-P280-P301+P312-P303+P361+P353-P330-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Rinse mouth. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,9307
Beilstein
103852
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2934.10
TSCA
Yes
RTECS
XJ1290000

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