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Calcein sodium salt is used as an indicator for the complexometric determination of calcium and magnesium. It is also used as an indicator for the determination of calcium in biological systems.
V.C.Chiu; D.H.Haynes; V.C.Chiu; D.H.Haynes. High and low affinity Ca2+ binding to the sarcoplasmic reticulum: use of a high-affinity fluorescent calcium indicator. Biophysical Journal. 1977, 18, (1),3-22
Martin Knopfel; Georg Schulthess; Felix Funk; Helmut Hauser. Characterization of an integral protein of the brush border membrane mediating the transport of divalent metal ions. Biophysical Journal. 2000, 79, (2),874-884
Reagent for complexometric determination of Ca and Mg: Analyst, 82, 284 (1957); 83, 188 (1958).