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7481-89-2 - 2',3'-Dideoxycytidine, 98+% - Zalcitabine - L10619 - Alfa Aesar

L10619 2',3'-Dideoxycytidine, 98+%

CAS Number
7481-89-2
Synonyms
Zalcitabine

Size Price ($) Quantity Availability
50mg 57.06
250mg 201.88
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2',3'-Dideoxycytidine, 98+%

MDL
MFCD00012188

Chemical Properties

Formula
C9H13N3O3
Formula Weight
211.22
Melting point
216-220°
Solubility
Soluble in water (76.4 mg/ml at 25°C), DMSO (42 mg/ml at 25°C), and ethanol (<1 mg/ml at 25°C).

Applications

2',3'-Dideoxycytidine in cells, it is phosphorylated to the active triphosphate form, ddCTP, which acts as a substrate for HIV reverse transcriptase (Ki = 51 nM). It incorporates into viral DNA where it terminates chain elongation when the missing hydroxyl group is encountered. It is also is used as a DNA chain-terminating nucleotide for DNA sequencing methods based on the Sanger chain-termination method.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

E.Ullyatt; B.C.Liang. 2',3'-Dideoxycytidine is a potent inducer of apoptosis in glioblastoma cells. Anticancer Research. 1998, 18, (3A),1859-1863

 

C.H.Chen; Y.C.Cheng. Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine. The Journal of Biological Chemistry. 1989, 264, (20),11934-11937

GHS Hazard and Precautionary Statements

Hazard Statements: H351-H361

Suspected of causing cancer. Suspected of damaging fertility or the unborn child.

Precautionary Statements: P201-P281-P202-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,10109
Beilstein
654956
Harmonized Tariff Code
2934.99
TSCA
No
RTECS
HA3870000

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