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A useful method for epoxidation of alkenes with hydrogen peroxide in the presence of a catalytic amount (ca 1-5 mol%) of hexafluoroacetone trihydrate has been reported by R. A. Sheldon. In chloroform or DCM, reaction is relatively slow and yields moderate; with 1,1,1,3,3,3-Hexafluoro-2-propanol, A12747, as reaction medium, excellent yields of epoxides are obtained after a few hours at room temperature: Synlett, 1305 (2001)./n
Hazard Statements: H301-H310+H330-H315-H318-H335-H361
Toxic if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation. Suspected of damaging fertility or the unborn child.
Precautionary Statements: P201-P202-P260-P262-P264b-P270-P271-P281-P284-P301+P310-P302+P350-P304+P340-P305+P351+P338-P308+P313-P310-P330-P332+P313-P361-P363-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not breathe dust/fume/gas/mist/vapours/spray. Do not get in eyes, on skin, or on clothing. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Gently wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation occurs: Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant