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3554-74-3 - 3-Hydroxy-1-methylpiperidine, 98% - 1-Methyl-3-piperidinol - L10829 - Alfa Aesar

L10829 3-Hydroxy-1-methylpiperidine, 98%

CAS Number
3554-74-3
Synonyms
1-Methyl-3-piperidinol

Size Price ($) Quantity Availability
5g 17.77
25g 59.40
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3-Hydroxy-1-methylpiperidine, 98%

MDL
MFCD00006495
EINECS
222-609-2

Chemical Properties

Formula
C6H13NO
Formula Weight
115.18
Boiling Point
76-78°/11mm
Flash Point
70°(158°F)
Density
0.999
Refractive Index
1.4740
Solubility
Fully misicible in water.

Applications

Reactant for Optimization of Novobiocin scaffold to produce antitumor agents, Formation of carbamates and N-alkylimidazoles. Reactant for synthesis of Pyridine derivatives as CDK5 inhibitors Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors, Amino phosphite ligands, Mexiletine enantiomers by nucleophilic aromatic substitution.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Huiping Zhao et. al. Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents.. Journal of medicinal and pharmaceutical chemistry,. 2007, 54 (11), 3839-3853.

Matthew R. Kaller et. al. Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19 (23), 6591-6594.

The Na derivative can be used in combination with Ni(OAc) 2 /NaH for desufurization of thioethers, showing dramatic rate enhancement compared with other systems: Tetrahedron Lett ., 39, 8987 (1998).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335-H227

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Precautionary Statements: P210-P261-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
103017
Harmonized Tariff Code
2933.39
TSCA
Yes

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