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Reactant for Optimization of Novobiocin scaffold to produce antitumor agents, Formation of carbamates and N-alkylimidazoles. Reactant for synthesis of Pyridine derivatives as CDK5 inhibitors Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors, Amino phosphite ligands, Mexiletine enantiomers by nucleophilic aromatic substitution.
Huiping Zhao et. al. Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents.. Journal of medicinal and pharmaceutical chemistry,. 2007, 54 (11), 3839-3853.
Matthew R. Kaller et. al. Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19 (23), 6591-6594.
The Na derivative can be used in combination with Ni(OAc) 2 /NaH for desufurization of thioethers, showing dramatic rate enhancement compared with other systems: Tetrahedron Lett ., 39, 8987 (1998).
Hazard Statements: H227-H315-H319-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P235-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep cool. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant