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2026-48-4 - L-(+)-Valinol, 97% - (S)-(+)-2-Amino-3-methyl-1-butanol - H-Val-ol - L11300 - Alfa Aesar

L11300 L-(+)-Valinol, 97%

CAS Number
2026-48-4
Synonyms
(S)-(+)-2-Amino-3-methyl-1-butanol
H-Val-ol

Size Price ($) Quantity Availability
1g 36.77
5g 129.15
25g 408.80
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L-(+)-Valinol, 97%

MDL
MFCD00064296
EINECS
217-975-5

Chemical Properties

Formula
C5H13NO
Formula Weight
103.17
Melting point
30-35°
Boiling Point
80-81°/8mm
Flash Point
78°(172°F)
Density
0.926
Refractive Index
1.4548
Sensitivity
Air Sensitive
Solubility
Soluble in water.

Applications

L-(+)-Valinol reacts with aldehydes and nitriles to form imines and oxazolines, respectively, for asymmetric synthesis. It is also used for preparation of 4-isopropyloxazolidinones, employed in stereocontrolled aldol and alkylation reactions, synthesis of chiral 2-thiazolidinethiones for aldol reactions, asymmetric alkylation of condensation product with keto acids, asymmetric reactions of its amidines and imines and oxidation of N-protected derivative to the aldehyde.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. It is sensitive to air. Store under dry inert gas.

Literature References

Y. Turgut.; H. Hoşgoren. Synthesis of chiral monoaza-15-crown-5 ethers from l-valinol and the enantiomeric recognition of chiral amines and their perchlorates salts. Tetrahedron: Asymmetry: Asymmetry. 2003, 14 (23), 3815-3818.

Hongge Jia.; Masahiro Teraguchi.; Toshiki Aoki.; Yunosuke Abe.; Takashi Kaneko.; Shingo Hadano.; Takeshi Namikoshi.; Edy Marwanta. Two Modes of Asymmetric Polymerization of Phenylacetylene Having a l-Valinol Residue and Two Hydroxy Groups. Macromolecules. 2009, 42 (1), 17-19.

Chiral auxiliary and building block. See also (4S)-(-)-Isopropyl-2-oxazolidinone, A14029 for derived reagents.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319

Causes skin irritation. Causes serious eye irritation.

Precautionary Statements: P280-P264-P305+P351+P338-P362-P321-P332+P313-P337+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Wash with plenty of soap and water.

Other References

Beilstein
1719137
Harmonized Tariff Code
2922.19
TSCA
No

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