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4-(Aminomethyl)piperidine is used as a reagent for rapid cleavage of the Fmoc group in peptide synthesis, particularly recommended in conjunction with Fmoc-protected acid chlorides as the active species. It Is also used as a reactant for evaulated as a small molecule inhibitor of CD4-gp120 binding and as a reagent involved in solvothermal preparation of germanium oxide hydroxide 3D net zeotype, involved in zeolite synthesis and as a coupling agent for adhesive systems.
Louis A. Carpino.; Dean Sadat-Aalaee.; Michael Beyermann. Tris(2-aminoethyl)amine as substitute for 4-(aminomethyl)piperidine in the FMOC/polyamine approach to rapid peptide synthesis. J. Org. Chem. 1990, 55 (5), 1673-1675.
Michael Beyermann.; Michael Bienert.; Hartmut Niedrich.; Louis A. Carpino.; Dean Sadat-Aalaee. Rapid continuous peptide synthesis via FMOC amino acid chloride coupling and 4-(aminomethyl)piperidine deblocking. J. Org. Chem. 1990, 55 (2), 721-728.
Reagent for rapid cleavage of the Fmoc group in peptide synthesis, particularly recommended in conjunction with Fmoc-protected acid chlorides as the active species: J. Org. Chem., 55, 721 (1990). See also Tris(2-aminoethyl)amine, B21789. See Appendix 6.
Hazard Statements: H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.