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L11577 4-(Aminomethyl)piperidine, 98+%

CAS Number
7144-05-0
Synonyms
4-Piperidinemethylamine

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Bulk/Specialty

4-(Aminomethyl)piperidine, 98+%

MDL
MFCD00006007
EINECS
230-446-3

Chemical Properties

Formula
C6H14N2
Formula Weight
114.19
Melting point
23-25°
Boiling Point
199-200°
Flash Point
79°(174°F)
Refractive Index
1.4900
Storage & Sensitivity
Air Sensitive. Ambient temperatures.
Solubility
Soluble in water.

Applications

4-(Aminomethyl)piperidine is used as a reagent for rapid cleavage of the Fmoc group in peptide synthesis, particularly recommended in conjunction with Fmoc-protected acid chlorides as the active species. It Is also used as a reactant for evaulated as a small molecule inhibitor of CD4-gp120 binding and as a reagent involved in solvothermal preparation of germanium oxide hydroxide 3D net zeotype, involved in zeolite synthesis and as a coupling agent for adhesive systems.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. It is sensitive to air.

Literature References

Louis A. Carpino.; Dean Sadat-Aalaee.; Michael Beyermann. Tris(2-aminoethyl)amine as substitute for 4-(aminomethyl)piperidine in the FMOC/polyamine approach to rapid peptide synthesis. J. Org. Chem. 1990, 55 (5), 1673-1675.

Michael Beyermann.; Michael Bienert.; Hartmut Niedrich.; Louis A. Carpino.; Dean Sadat-Aalaee. Rapid continuous peptide synthesis via FMOC amino acid chloride coupling and 4-(aminomethyl)piperidine deblocking. J. Org. Chem. 1990, 55 (2), 721-728.

Reagent for rapid cleavage of the Fmoc group in peptide synthesis, particularly recommended in conjunction with Fmoc-protected acid chlorides as the active species: J. Org. Chem., 55, 721 (1990). See also Tris(2-aminoethyl)­amine, B21789. See Appendix 6.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H302-H312-H314-H332

Combustible liquid. Harmful if swallowed. Harmful in contact with skin. Causes severe skin burns and eye damage. Harmful if inhaled.

Precautionary Statements: P210-P233-P240-P243-P260-P264b-P270-P271-P280-P301+P312-P303+P361+P353-P304+P340-P305+P351+P338-P310-P312-P330-P331-P363-P374-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Fight fire with normal precautions from a reasonable distance. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
471185
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2933.39
TSCA
Yes

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