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486-56-6 - (-)-Cotinine, 98% - (S)-(-)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone - L11873 - Alfa Aesar

L11873 (-)-Cotinine, 98%

CAS Number
486-56-6
Synonyms
(S)-(-)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone

Size Price ($) Quantity Availability
250mg 55.62
1g 130.81
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(-)-Cotinine, 98%

MDL
MFCD00077696
EINECS
207-634-9

Chemical Properties

Formula
C10H12N2O
Formula Weight
176.22
Melting point
34-39°
Boiling Point
145-147°/3mm
Flash Point
>110°(230°F)
Solubility
Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform.

Applications

(-)-Cotinine is used to activate a subpopulation of α3/ α6β2 nAChRs in monkey striatum. It binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature is 2 - 8°C.

Literature References

Neal L Benowitz MD.; Peyton Jacob III PhD. Metabolism of nicotine to cotinine studied by a dual stable isotope method. Clinical Pharmacology & Therapeutics. 1994, 56 (5), 483-493.

N J Haley.; C M Axelrad.; K A Tilton. Validation of self-reported smoking behavior: biochemical analyses of cotinine and thiocyanate. American Journal of Public Health. 1983, 73 (10), 1204-1207.

Nicotine metabolite: J. Chromat., 231, 53 (1982).

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2553
Beilstein
83099
Harmonized Tariff Code
2933.79
TSCA
No
RTECS
GN1925500

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