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298-93-1 - Thiazolyl Blue tetrazolium bromide, 98% - 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide - MTT - L11939 - Alfa Aesar

L11939 Thiazolyl Blue tetrazolium bromide, 98%

CAS Number
298-93-1
Synonyms
3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide
MTT

Size Price ($) Quantity Availability
1g 43.20
5g 132.00
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Thiazolyl Blue tetrazolium bromide, 98%

MDL
MFCD00011964
EINECS
206-069-5

Chemical Properties

Formula
C18H16BrN5S
Formula Weight
414.33
Melting point
ca 195° dec.
Sensitivity
Light, Air & Moisture Sensitive
Solubility
Soluble in water, ethanol, 2-methoxyethanol and phosphate buffered saline.

Applications

Used in measurement of cell proliferation. Produces a yellowish solution that is converted to dark blue, water-insoluble MTT formazan by mitochondrial dehydrogenases of living cells.Thiazolyl Blue tetrazolium bromide is a dye used in measurement of cell proliferation. It is used as a direct indicator of cytotoxicity (such as for screening cancer drugs) and apoptosis. As an electron acceptor, it is utilized for studying nicotinamide adenine dinucleotide phosphate (NADP)-dependent dehydrogenases.

Notes

Light, air and moisture sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Literature References

Ma, W.; Xu, A.; Ying, J.; Li, B.; Jin, Y. Biodegradable Core-Shell Copolymer-Phospholipid Nanoparticles for Combination Chemotherapy: An In Vitro Study. J. Biomed. Nanotechnol. 2015, 11 (7), 1193-1200.

Wei, D.; Chen, T.; Yan, M.; Zhao, W.; Li, F.; Cheng, W.; Yuan, L. Synthesis, characterization, antioxidant activity and neuroprotective effects of selenium polysaccharide from Radix hedysari. Carbohydr. Polym. 2015, 125, 161-168.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
3825277
Harmonized Tariff Code
2934.99
TSCA
Yes
RTECS
XF8060000

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