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3,5-Dichloro-2-hydroxybenzenesulfonyl chloride is used in the synthesis of (1R,2R)-(+)-1,2-(3,3?,5,5?-tetrachloro-2,2?-dihydroxydibenzenesulfonamido)-1,2-diphenylethane1 and (1R,2R)-(+)- 1,2-(3,3?,5,5?-tetrachloro-2,2?-dihydroxydibenzenesulfonamido)cyclohexane. It was used as chromogenic system in one-step kinetic method for the determination of 5?-nucleotidase.
A Bertrand; J Buret. A one-step determination of serum 5'-nucleotidase using a centrifugal analyzer. Clinica Chimica Acta.1982, 119, (3), 275-284.
Cheng Guo; Jun Qiu; Xumu Zhang; Dawn Verdugo; Martin L. Larter; Ray Christie; Patrick Kenney; Patrick J. Walsh. Enantioselective addition of diethylzinc to benzaldehyde catalyzed by chiral titanate complexes with helical ligands. Tetrahedron.1997, 53, 4145-4158.
Reagent for peptide coupling with low racemization: Tetrahedron Lett., 35, 9561 (1994). See Appendix 6. Reaction is thought to proceed via an o-thioquinone S,S-dioxide, leading to a carboxylic sulfonic mixed anhydride which rearranges to an active ester:
Hazard Statements: H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.