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23378-88-3 - 3,5-Dichloro-2-hydroxybenzenesulfonyl chloride, 97% - L12147 - Alfa Aesar

L12147 3,5-Dichloro-2-hydroxybenzenesulfonyl chloride, 97%

CAS Number
23378-88-3
Synonyms

Size Price ($) Quantity Availability
50g 159.00
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3,5-Dichloro-2-hydroxybenzenesulfonyl chloride, 97%

MDL
MFCD00007432
EINECS
245-619-9

Chemical Properties

Formula
C6H3Cl3O3S
Formula Weight
261.51
Melting point
78-80°
Sensitivity
Moisture Sensitive
Solubility
Hydrolyzes in water.

Applications

3,5-Dichloro-2-hydroxybenzenesulfonyl chloride is used in the synthesis of (1R,2R)-(+)-1,2-(3,3?,5,5?-tetrachloro-2,2?-dihydroxydibenzenesulfonamido)-1,2-diphenylethane1 and (1R,2R)-(+)- 1,2-(3,3?,5,5?-tetrachloro-2,2?-dihydroxydibenzenesulfonamido)cyclohexane. It was used as chromogenic system in one-step kinetic method for the determination of 5?-nucleotidase.

Notes

Moisture Sensitive. Incompatible with bases, moisture and oxidizing agents. Store under dry inert gas. Protect from humidity and water.

Literature References

A Bertrand; J Buret. A one-step determination of serum 5'-nucleotidase using a centrifugal analyzer. Clinica Chimica Acta.1982, 119, (3), 275-284.

Cheng Guo; Jun Qiu; Xumu Zhang; Dawn Verdugo; Martin L. Larter; Ray Christie; Patrick Kenney; Patrick J. Walsh. Enantioselective addition of diethylzinc to benzaldehyde catalyzed by chiral titanate complexes with helical ligands. Tetrahedron.1997, 53, 4145-4158.

Reagent for peptide coupling with low racemization: Tetrahedron Lett., 35, 9561 (1994). See Appendix 6. Reaction is thought to proceed via an o-thioquinone S,S-dioxide, leading to a carboxylic sulfonic mixed anhydride which rearranges to an active ester:

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2940993
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2908.99
TSCA
No

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