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455-16-3 - p-Toluenesulfonyl fluoride, 98% - Tosyl fluoride - L12204 - Alfa Aesar

L12204 p-Toluenesulfonyl fluoride, 98%

CAS Number
455-16-3
Synonyms
Tosyl fluoride

Size Price ($) Quantity Availability
25g 78.00
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p-Toluenesulfonyl fluoride, 98%

MDL
MFCD00007421
EINECS
207-238-6

Chemical Properties

Formula
C7H7FO2S
Formula Weight
174.19
Melting point
40-41°
Boiling Point
112°/16mm
Flash Point
105°(221°F)
Sensitivity
Moisture Sensitive
Solubility
Hydrolyzes in water.

Applications

p-Toluenesulfonyl fluoride is used for sulfonylation of organometallic reagents as a simple, one-step synthesis of sulfones. It is useful in the treatment of Alzheimer?s disease. It is used to study the DNS polymerase from spinach leaf extracts. It was used in isolation and separation of Pseudomonas aeruginosa membranes by density sucrose gradient centrifugation.

Notes

Moisture Sensitive. Incompatible with bases, moisture and oxidizing agents. Store under dry inert gas. Protect from humidity and water.

Literature References

F Sala; A R Amileni; B Parisi; S Spadari. A gamma-like DNA polymerase in spinach chloroplasts. European Journal of Biochemistry.1980, 112, (2), 211-217.

Véronique Viarre; Eric Cascales; Geneviève Ball; Gérard P F Michel; Alain Filloux; Romé Voulhoux. HxcQ liposecretin is self-piloted to the outer membrane by its N-terminal lipid anchor. Journal of Biological Chemistry.2009, 284, (49), 33815-33823.

For sulfonylation of organometallic reagents as a simple, one-step synthesis of sulfones, see: J. Org. Chem., 57, 697 (1992):

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H314-H318

Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260u-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a

IF SWALLOWED: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2208423
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2904.99
TSCA
Yes
RTECS
XT8050000

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