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p-Toluenesulfonyl fluoride is used for sulfonylation of organometallic reagents as a simple, one-step synthesis of sulfones. It is useful in the treatment of Alzheimer?s disease. It is used to study the DNS polymerase from spinach leaf extracts. It was used in isolation and separation of Pseudomonas aeruginosa membranes by density sucrose gradient centrifugation.
F Sala; A R Amileni; B Parisi; S Spadari. A gamma-like DNA polymerase in spinach chloroplasts. European Journal of Biochemistry.1980, 112, (2), 211-217.
Véronique Viarre; Eric Cascales; Geneviève Ball; Gérard P F Michel; Alain Filloux; Romé Voulhoux. HxcQ liposecretin is self-piloted to the outer membrane by its N-terminal lipid anchor. Journal of Biological Chemistry.2009, 284, (49), 33815-33823.
For sulfonylation of organometallic reagents as a simple, one-step synthesis of sulfones, see: J. Org. Chem., 57, 697 (1992):
Hazard Statements: H301-H314-H318
Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
Do not breathe dusts or mists. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.