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1122-28-7 - 4,5-Dicyanoimidazole, 98+% - Imidazole-4,5-dicarbonitrile - L12215 - Alfa Aesar

L12215 4,5-Dicyanoimidazole, 98+%

CAS Number
1122-28-7
Synonyms
Imidazole-4,5-dicarbonitrile

Size Price ($) Quantity Availability
5g 26.90
25g 91.20
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4,5-Dicyanoimidazole, 98+%

MDL
MFCD00005194
EINECS
214-344-6

Chemical Properties

Formula
C5H2N4
Formula Weight
118.10
Melting point
173-177°
Solubility
Soluble in Acetonitrile: 1.8g/10ml, DMSO, Methanol.

Applications

4,5-Dicyanoimidazole is used in activation of nucleoside phosphoramidites during solid-phase oligonucleotide synthesis, and synthesis of nucleoside phosphoramidites, synthesis of novel nucleosides. It is often used as an alternative to tetrazole.

Notes

Store in a cool, dry conditions in well sealed container. Incompatible with oxidizing agents.

Literature References

Chandra Vargeese; Jeff Carter; John Yegge; Shira Krivjansky; Alecia Settle; Eric Kropp; Kent Peterson and Wolfgang Pieken. Efficient activation of nucleoside phosphoramidites with 4,5-dicyanoimidazole during oligonucleotide synthesis. Nucl. Acids Res.1998, 26, (4), 1046-1050.

Paul G. Apen; Paul G. Rasmussen. Synthesis and properties of new derivatives of 4,5-dicyanoimidazole and 4,4',5,5'-tetracyano-2,2'-biimidazole. J. Am. Chem. Soc.1991, 113, (16), 6178-6187.

GHS Hazard and Precautionary Statements

Hazard Statements: H318-H315-H302-H335

Causes serious eye damage. Causes skin irritation. Harmful if swallowed. May cause respiratory irritation.

Precautionary Statements: P280h-P305+P351+P338

Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Other References

Beilstein
118208
Harmonized Tariff Code
2933.29
TSCA
No

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