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L12215 4,5-Dicyanoimidazole, 98+%

CAS Number
1122-28-7
Synonyms
Imidazole-4,5-dicarbonitrile

Stock No. Size Price ($) Quantity Availability
L12215-06 5g 29.00
L12215-14 25g 97.20
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4,5-Dicyanoimidazole, 98+%

MDL
MFCD00005194
EINECS
214-344-6

Chemical Properties

Formula
C5H2N4
Formula Weight
118.10
Melting point
173-177°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in Acetonitrile: 1.8g/10ml, DMSO, Methanol.

Applications

4,5-Dicyanoimidazole is used in activation of nucleoside phosphoramidites during solid-phase oligonucleotide synthesis, and synthesis of nucleoside phosphoramidites, synthesis of novel nucleosides. It is often used as an alternative to tetrazole.

Notes

Store in a cool, dry conditions in well sealed container. Incompatible with oxidizing agents.

Literature References

Chandra Vargeese; Jeff Carter; John Yegge; Shira Krivjansky; Alecia Settle; Eric Kropp; Kent Peterson and Wolfgang Pieken. Efficient activation of nucleoside phosphoramidites with 4,5-dicyanoimidazole during oligonucleotide synthesis. Nucl. Acids Res.1998, 26, (4), 1046-1050.

Paul G. Apen; Paul G. Rasmussen. Synthesis and properties of new derivatives of 4,5-dicyanoimidazole and 4,4',5,5'-tetracyano-2,2'-biimidazole. J. Am. Chem. Soc.1991, 113, (16), 6178-6187.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H318-H335

Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P312-P332+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
118208
Harmonized Tariff Code
2933.29
TSCA
No

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