Ethyl 2-nitropropionate is used in the preparation of (-)-trans-2,5-dimethylprolineethyl ester via enantioselective Michael reaction methyl vinyl ketone using modified dihydroquinine as catalyst, novel nitrogen-15-labeled nitrone spin trap, 5-ethoxycarbonyl-5-methyl-1-pyrroline N-oxide ([15N]EMPO) for detecting superoxide anion, 2-ethoxycarbonyl-2-nitropentanal. It is used for enantioselective Michael reactions.
Jeremy R Duvall; Fanghui Wu; Barry B Snider. Structure reassignment and synthesis of Jenamidines A1/A2, synthesis of (+)-NP25302, and formal synthesis of SB-311009 analogues. J. Org. Chem.2006, 71, (22), 8579-8590.
H Zhang; J Joseph; J Vasquez-Vivar; H Karoui; C Nsanzumuhire; P Martásek; P Tordo; B Kalyanaraman. FEBS Letters.2000, 473, (1), 58-62.
Hazard Statements: H227-H315-H319-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210u-P261-P280a-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.