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James A. Marshall.; Thomas M. WarneJr. Total synthesis of (+-)-isonootkatone. Stereochemical studies of the Robinson annelation reaction with 3-penten-2-one. J. Org. Chem. 1971, 36 (1), 178-183.
J. Peter Guthrie. The retroaldol reaction of 3-penten-2-one: equilibrium constant for hydration and rate constants for the hydration and retroaldol reactions in base. Canadian Journal of Chemistry. 1981, 59 (1), 45-49.
Undergoes conjugate addition with Ethyl nitroacetate, A14433. The resulting -nitro ketone can be reductively cyclized to a pyrrole in high yield: Tetrahedron Lett., 36, 9469 (1995):
Hazard Statements: H225-H312-H315-H319-H335
Highly flammable liquid and vapour. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P261-P264b-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P363-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant