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5781-53-3 - Methyl oxalyl chloride, 97% - Methyl chloroglyoxylate - L13258 - Alfa Aesar

L13258 Methyl oxalyl chloride, 97%

CAS Number
5781-53-3
Synonyms
Methyl chloroglyoxylate

Size Price ($) Quantity Availability
5g 30.80
25g 90.30
100g 261.00
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Methyl oxalyl chloride, 97%

MDL
MFCD00000705
EINECS
227-307-4

Chemical Properties

Formula
C3H3ClO3
Formula Weight
122.51
Boiling Point
115-118°
Flash Point
46°(114°F)
Density
1.332
Refractive Index
1.4190
Sensitivity
Moisture Sensitive
Solubility
Miscible with water.

Applications

Methyl oxalyl chloride is used as a synthetic reagent. It serves as a reagent in the synthesis of fused coumarins, substituted isoxazoles and heterocycles. Further, it is used in intramolecular Wittig reactions, and iron-mediated cleavage of C-C bonds.

Notes

Moisture sensitive. Incompatible with water, oxidizing agents, alcohols and bases.

Literature References

Zhao, L.; Yang, H. J.; Cai, Z. Solubility comparison and partial molar volumes of 1, 2-hexanediol before and after end-group modification by methyl oxalyl chloride and ethyl oxalyl monochloride in supercritical CO2. J. Chem. Thermodyn. 2013, 57, 46-53.

Fandrick, K. R.; Li, W.; Zhang, Y.; Tang, W.; Gao, J.; Rodriguez, S.; Patel, N. D.; Reeves, D. C.; Wu, J. P.; Sanyal, S.; Gonnella, N.; Qu, B.; Haddad, N.; Lorenz, J. C.; Sidhu, K.; Wang, J.; Ma, S.; Grinberg, N.; Lee, H.; Tsantrizos, Y.; Poupart, M. A.; Busacca, C. A.; Yee, N. K.; Lu, B. Z.; Senanayake, C. H. Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor. Angew. Chem. 2015, 127 (24), 7250-7254.

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H302-H314-H318

Flammable liquid and vapour. Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1071541
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2917.19
TSCA
Yes

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