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Potassium hydride is a precursor in the production of various bases by deprotonation, highly-hindered bases potassium triethylmethoxide and potassium 3-aminopropylamide It serves as a powerful base in organic synthesis of deprotonate carbonyl compounds and amines to form enolates and amides respectively.
Used catalytically to initiate deprotonation of a ketone with sodium hydride: Org. Synth. Coll ., 7, 351 (1990).
Has been used to generate various bases by deprotonation; e.g. the highly-hindered bases potassium triethylmethoxide: Synthesis, 427 (1974), and potassium 2,6-di-t-butylphenoxide (see 2,6-Di-tert-butylphenol, A17244). For generation of the strong base potassium 3-aminopropylamide (KAPA), see 1,3-Diaminopropane, A11932.
o-Alkynylanilines cyclize to indoles with KH in NMP; NaH is ineffective: Angew. Chem. Int. Ed., 39, 2488 (2000):
Szcz?śniak, D.; Szcz?śniak, R. Thermodynamics of the hydrogen dominant potassium hydride superconductor at high pressure. Solid State Commun. 2015, 212, 1-4.
Durojaiye, T.; Hayes, J.; Goudy, A. Potassium, rubidium and cesium hydrides as dehydrogenation catalysts for the lithium amide/magnesium hydride system. Int. J. Hydrogen Energy. 2015, 40 (5), 2266-2273.
Hazard Statements: H260-H304-H314-H335
In contact with water releases flammable gases which may ignite spontaneously. May be fatal if swallowed and enters airways. Causes severe skin burns and eye damage. May cause respiratory irritation.
Precautionary Statements: P223-P231+P232-P260-P264b-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P335+P334-P363-P370+P378q-P501c
Keep away from any possible contact with water, because of violent reaction and possible flash fire. Handle under inert gas. Protect from moisture. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant