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L13363 1-Boc-piperazine, 99%

CAS Number
tert-Butyl 1-piperazinecarboxylate

Stock No. Size Price ($) Quantity Availability
L13363-03 1g 26.10
L13363-06 5g 93.50
L13363-14 25g 367.00
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1-Boc-piperazine, 99%


Chemical Properties

Formula Weight
Melting point
Storage & Sensitivity
Air Sensitive. Store under Nitrogen. Ambient temperatures.
Soluble in ethyl acetate, methanol and water.


1-Boc-piperazine is useful for the preparation of (m-phenoxy)phenyl substituted piperazine derivatives. It is also used in the synthesis of indazole DNA gyrase inhibitors. Further, it plays an important role in the preparation of alfa,beta-poly(2-oxazoline) lipopolymers through living cationic ring opening polymerization. It is also in involved in Buchwald-Hartwig coupling reactions with aryl halides.


Hygroscopic. Store in a cool place. Moisture sensitive. Incompatible with strong oxidizing agents.

Literature References

Pd-catalyzed C-N coupling with a variety of bromoarenes, in the presence of NaO-t-Bu and Tri(o-tolyl)­phosphine, A12093, provides a route to arylpiperazines of potential pharmacological interest: Tetrahedron Lett., 39, 2219 (1998).

Ba-Salem, A. O.; Shaikh, M. N.; Ullah, N.; Faiz, M. Synthesis and magnetic relaxation properties of new Gd(III) complexes derived from DTPA-bis(amide) conjugates of arylpiperazinyl amines. Inorg. Chem. Commun. 2015, 56, 5-7.

Nemeckova-Herova, D.; Pazdera, P. A Simplified Protocol for Routine Chemoselective Syntheses of Piperazines Substituted in the 1-Position by an Electron Withdrawing Group. Curr. Org. Synth. 2015, 12 (2), 173-179.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code


  • A10296

    Benzoin methyl ether, 97%
  • A10807

    1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 98+%
  • A11118

    2,2'-Dipyridyl disulfide, 98%
  • A11606

    1-Propylamine, 98%
  • A14149

    1,3-Dichloroacetone, 96%

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