I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Trimethyl orthoacetate is used as a diols can be protected as their 1-methoxyethylidene cyclic acetals (2-methoxy-2-methyl-1,3-dioxolanes) by acid-catalyzed exchange. It is mainly used as the chemical intermediates of the medicine. Some of the other applications includes it is mainly used as chemical intermediate of pharmaceutical and agricultural chemicals, used for compound medical intermediates of vitamin B1, vitamin A1 and sulfanilamide organism, used for dye and spices industry, Medicine, agricultural chemicals, paint additives.
HPM Fromageot.; BE Griffin.; CB Reese.; JE Sulston. The synthesis of oligoribonucleotidesIII: Monoacrylation of ribonucleosides and derivativesvia orthoester exchange. Tetrahedron. 1967, 23,(5), 2315-2331.
T Yoshino.; S Imori.; H Togo. Efficient esterification of carboxylic acids and phosphonic acids with trialkyl orthoacetate in ionic liquid. Tetrahedron. 2006, 62,(6), 1309-1317.
Diols can be protected as their 1-methoxyethylidene cyclic acetals (2-methoxy-2-methyl-1,3-dioxolanes) by acid-catalyzed exchange; see, e.g.: J. Am. Chem. Soc., 95, 278 (1973). See also Triethyl orthoacetate, L06004.
Hazard Statements: H225-H315-H317-H319
Highly flammable liquid and vapour. Causes skin irritation. May cause an allergic skin reaction. Causes serious eye irritation.
Precautionary Statements: P210-P233-P240-P241-P242-P243-P261-P264b-P272-P280-P303+P361+P353-P305+P351+P338-P333+P313-P337+P313-P363-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If skin irritation or rash occurs: Get medical advice/attention. If eye irritation persists: Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant