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612-23-7 - 2-Nitrobenzyl chloride, 98+% - alpha-Chloro-2-nitrotoluene - L13599 - Alfa Aesar

L13599 2-Nitrobenzyl chloride, 98+%

CAS Number
612-23-7
Synonyms
alpha-Chloro-2-nitrotoluene

Size Price ($) Quantity Availability
5g 54.40
25g 207.00
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2-Nitrobenzyl chloride, 98+%

MDL
MFCD00007185
EINECS
210-300-5

Chemical Properties

Formula
C7H6ClNO2
Formula Weight
171.58
Melting point
47-51°
Boiling Point
127-133°/10mm
Flash Point
>110°(230°F)
Density
1.556
Solubility
Soluble in acetone, alcohol benzene, diethyl ether, and ethanol (98%). Insoluble in water.

Applications

2-Nitrobenzyl chloride has been used to introduce the photo labile 2-nitrobenzyl protecting group for the phenolic OH group of tyrosine. It is used as a pharmaceutical intermediate.

Notes

Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.

Literature References

DR Knapp.; S Krueger. Use of Op-nitrobenzyl-N, N?-diisopropylisourea as a chromogenic reagent for liquid chromatographic analysis of carboxylic acids. Analytical Letters. 1975, 8,(9), 603-610.

G Giuglio-Tonolo.; T Terme.; M Médebielle.; P Vanelle. Nitrobenzylation of α-carbonyl ester derivatives using TDAE approach. Tetrahedron letters. 2004, 45,(26), 5121-5124.

Has been used to introduce the photolabile 2-nitrobenzyl protecting group for the phenolic OH group of tyrosine: Int. J. Pept. Protein Res., 9, 91 (1977).

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318-H341

Causes severe skin burns and eye damage. Causes serious eye damage. Suspected of causing genetic defects.

Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
388396
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2903.99
TSCA
No
RTECS
XS9092000

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