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2-Nitrobenzyl chloride has been used to introduce the photo labile 2-nitrobenzyl protecting group for the phenolic OH group of tyrosine. It is used as a pharmaceutical intermediate.
DR Knapp.; S Krueger. Use of Op-nitrobenzyl-N, N?-diisopropylisourea as a chromogenic reagent for liquid chromatographic analysis of carboxylic acids. Analytical Letters. 1975, 8,(9), 603-610.
G Giuglio-Tonolo.; T Terme.; M Médebielle.; P Vanelle. Nitrobenzylation of α-carbonyl ester derivatives using TDAE approach. Tetrahedron letters. 2004, 45,(26), 5121-5124.
Has been used to introduce the photolabile 2-nitrobenzyl protecting group for the phenolic OH group of tyrosine: Int. J. Pept. Protein Res., 9, 91 (1977).
Hazard Statements: H314-H318-H341
Causes severe skin burns and eye damage. Causes serious eye damage. Suspected of causing genetic defects.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.