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20859-02-3 - L-tert-Leucine, 99% - (S)-2-Amino-3,3-dimethylbutyric acid - L-2-tert-Butylglycine - L13707 - Alfa Aesar

L13707 L-tert-Leucine, 99%

CAS Number
20859-02-3
Synonyms
(S)-2-Amino-3,3-dimethylbutyric acid
L-2-tert-Butylglycine

Size Price ($) Quantity Availability
1g 41.41
5g 130.81
25g 515.00
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L-tert-Leucine, 99%

MDL
MFCD00064218
EINECS
424-750-7

Chemical Properties

Formula
C6H13NO2
Formula Weight
131.18
Melting point
>300°
Solubility
Soluble in water and hydrchloric acid.

Applications

L-tert-Leucine is an essential amino acid and makes up one third of our muscle protein. It can be used as a food additive. It is used in the formation of sterols. It is used in the production of cobalt oxazoline palladacycles complex, which acts as a catalyst in the rearrangement of prochiral N-aryl trifluoroacetimidates to allylic amides yielded in significantly higher enantioselectivities with the (S)-(<sub>p</sub>R)-diasteroisomer.

Notes

Incompatible with strong oxidizing agents.

Literature References

ɑ-Amino acids have been used in combination with NaBH4 for the asymmetric reduction of ketones. Of a number of amino acids the sterically hindered tert-leucine was found to give the highest ee (95%) in the reduction of the carbonyl group of a 1,5-benzothiazepine intermediate in an efficient synthesis of the calcium antagonist diltiazem: J. Org. Chem., 61, 8586 (1996).

Li, J.; Pan, J.; Zhang, J.; Xu, J. H. Stereoselective synthesis of l-tert-leucine by a newly cloned leucine dehydrogenase from Exiguobacterium sibiricum. J. Mol. Catal. B: Enzym. 2014, 105, 11-17.

Liu, W.; Luo, J.; Zhuang, X.; Shen, W.; Zhang, Y.; Li, S.; Hu, Y.; Huang, H. Efficient preparation of enantiopure L-tert-leucine through immobilized penicillin G acylase catalyzed kinetic resolution in aqueous medium. Biochem. Eng. J. 2014, 83, 116-120.

Other References

Beilstein
1721824
Harmonized Tariff Code
2922.49
TSCA
No

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