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5344-27-4 - 4-(2-Hydroxyethyl)pyridine, 98% - 4-Pyridineethanol - 2-(4-Pyridyl)ethanol - L13780 - Alfa Aesar

L13780 4-(2-Hydroxyethyl)pyridine, 98%

CAS Number
5344-27-4
Synonyms
4-Pyridineethanol
2-(4-Pyridyl)ethanol

Size Price ($) Quantity Availability
1g 57.40
5g 193.00
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4-(2-Hydroxyethyl)pyridine, 98%

MDL
MFCD00129038
EINECS
226-286-9

Chemical Properties

Formula
C7H9NO
Formula Weight
123.16
Melting point
8-10°
Boiling Point
121-122°/2mm
Flash Point
92°(197°F)
Density
1.093
Refractive Index
1.5380
Sensitivity
Hygroscopic
Solubility
Miscible with water.

Applications

4-(2-Hydroxyethyl)pyridine acts as a reagent for the protection of carboxyl groups as their 2-(4-pyridyl)ethyl esters in organic synthesis. Further, it is used as an active pharmaceutical ingredient intermediate.

Notes

Hygroscopic. Moisture sensitive. Incompatible with strong oxidizing agents, bases and mineral acids.

Literature References

Reagent for protection of carboxyl groups as their 2-(4-pyridyl)ethyl esters, by reaction with the acid chloride: Tetrahedron Lett., 25, 1223 (1984). See preceding entry under 2-isomer. See also 4-Vinyl­pyridine, L13316.

Kato, Y.; Kawasaki, M.; Nigo, T.; Nakamura, S.; Fusano, A.; Teranishi, Y.; Ito, M. N.; Sumiyoshi, T. Identification of 2,3-disubstituted pyridines as potent, orally active PDE4 inhibitors. Bioorg. Med. Chem. 2013, 21 (18), 5851-5854.

Aschenbrücker, J.; Steegmüller, U.; Ernsting, N. P.; Buback, M.; Schroeder, J.; Jasny, J. Picosecond UV pump/IR probe spectrometer for the 2-5 mum spectral region. Appl. Phys. B: Lasers Opt. 1997, 65 (4), 441-444.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H303-H315-H319-H335

Combustible liquid. May be harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210u-P261-P280a-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
111361
Harmonized Tariff Code
2933.39
TSCA
Yes
RTECS
UT2971000

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