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Urea hydrogen peroxide is an antiseptic, disinfectant and bleaching agent used in pharmaceuticals and cosmetics respectively. It is used in the whitening of teeth and relieves minor inflammation of gums, oral mucosal surfaces and lips. It finds application in the preparation of plastics, blue print development and starch modification. In addition to this, it is used as a source of hydrogen peroxide easily handled in the laboratory.
Useful, low-hazard alternative to high-concentration H2O2 in epoxidations, Baeyer-Villiger reactions, N-oxidations, etc.: Synlett, 533 (1990). Alkenes can be epoxidized in high yield in 1,1,1,3,3,3-Hexafluoro-2-propanol, A12747 as solvent: Eur. J. Org. Chem., 3290 (2002). For use in combination with N,N'-Dicyclohexylcarbodiimide, A10973 , in epoxidation of alkenes, see: J. Org. Chem., 63, 1730 (1998); in combination with Maleic anhydride, A12178 , for epoxidation and Baeyer-Villiger reactions: Heterocycles, 36, 1075 (1993). For an extensive review of the Baeyer-Villiger reaction, see: Org. React., 43, 251 (1993).
For use in partial oxidation of nitriles to amides, see: Synth. Commun., 23, 3149 (1993).
In combination with phthalic anhydride is an effective mild and safe oxidant for N-heteroaromatic compounds and tertiary amines to N-oxides: Chem. Ber., 125, 1965 (1992)
Can be used to generate the powerful oxidant peroxytrifluoroacetic acid from TFAA, avoiding the use of hazardous 90% H2O2: Tetrahedron Lett., 33, 4835 (1992). The same system has also been reported for oxidation of electron-deficient pyridines to the N-oxides: Tetrahedron Lett., 41, 2299 (2000). Similarly, performic acid can be generated in situ, providing a mild system for oxidation of aromatic aldehydes to benzoic acids: Synth. Commun., 31, 2195 (2001). See also Sodium percarbonate, A16045 .
Yazu, K.; Takanohashi, T. Oxidative Desulfurization of Coal Tar Pitch Using a Urea-Hydrogen Peroxide Complex/Carboxylic Anhydride System in THF. Chem. Lett. 2015, 44 (2), 169-170.
Nikoorazm, M.; Ghorbani-Choghamarani, A.; Ghorbani, F.; Mahdavi, H.; Karamshahi, Z. Bidentate salen Cu(II) complex functionalized on mesoporous MCM-41 as novel nano catalyst for the oxidative coupling of thiols into disulfides using urea hydrogen peroxide (UHP). J. Porous Mater. 2015, 22 (1), 261-267.
Hazard Statements: H272-H314-H335
May intensify fire; oxidizer. Causes severe skin burns and eye damage. May cause respiratory irritation.
Precautionary Statements: P210-P220-P221-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep/Store away from clothing/combustible materials. Take any precaution to avoid mixing with combustibles. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant