Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

133745-75-2 - N-Fluorobenzenesulfonimide, 97% - AccuFluor NFSi - N-Fluorobis(phenylsulfonyl)amine - L13955 - Alfa Aesar

L13955 N-Fluorobenzenesulfonimide, 97%

CAS Number
AccuFluor NFSi

Size Price ($) Quantity Availability
1g 23.40
5g 70.20
25g 251.00
Add to Cart Add to Quote Request View Item

N-Fluorobenzenesulfonimide, 97%


Chemical Properties

Formula Weight
Melting point
Very soluble in acetonitrile, dichloromethane or THF and less soluble in toluene.


N-Fluorobenzenesulfonimide fluorinates aromatics, enolates, azaenolates and carbanions in high yield. It is used for diastereoselective fluorination of Li enolates of chiral carboximides, for directed fluorination of ortho-lithiated aromatics and for a review of electrophilic N-F fluorinating agents. Asymmteric fluorinations is effected in the presence of a Pd-BINAP catalyst system at room temperature in an ionic liquid. It is a reagent employed in a palladium-catalyzed enantioselective fluorination of t-butoxycarbonyl lactones and lactams. It is also used in the electrophilic difluorination of dihalopyridines with butyl lithium and in the direct conversion of alcohols to dibenzenesulfonamides with triphenylphosphine.


Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agents.

Literature References

Anthony A Fodor.; Richard W Aldrich. Statistical limits to the identification of ion channel domains by sequence similarity. Journal of General Physiology. 2006, 127 (6), 755-766.

Paul A. Sibbald.; Forrest E. Michael. Palladium-Catalyzed Diamination of Unactivated Alkenes Using N-Fluorobenzenesulfonimide as Source of Electrophilic Nitrogen. Org. Lett. 2009, 11 (5), 1147-1149.

Stable, non-hygroscopic, glass-compatible mild electrophilic fluorinating agent, very soluble in acetonitrile, dichloromethane or THF, less soluble in toluene. Fluorinates aromatics, enolates, azaenolates and carbanions in high yield: Synlett, 187, 395 (1991); Tetrahedron Lett., 32, 1631 (1991); for diastereoselective fluorination of Li enolates of chiral carboximides, see: Tetrahedron Lett., 33, 1153 (1992). Asymmteric fluorinations have been effected in the presence of a Pd-BINAP catalyst system at room temperature in an ionic liquid: Org. Lett., 5, 3225 (2003).

For directed fluorination of ortho-lithiated aromatics, see: Tetrahedron Lett., 35, 3465 (1994); ɑɑ-difluorination of benzylic phosphonate anions: Tetrahedron, 54, 1691 (1998); andof benzylic nitriles, tetrazoles and sulfonates: J. Org. Chem., 63, 8052 (1998).

For a review of electrophilic N-F fluorinating agents, see: Chem. Rev., 96, 1737 (1996).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code


  • A10563

    2-Iodobenzoic acid, 98+%
  • A10788

    2,2,2-Trifluoroethanol, 99+%
  • A11116

    Tryptamine, 98+%
  • A12535

    Trimethylsilyl trifluoromethanesulfonate, 99%
  • L17003

    1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), 98+%

Recently Viewed


Life Science

Metals & Materials


Analytical & Labware