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4,5-Dimethoxy-2-nitrobenzyl chloroformate is used as a reagent for protection of amines, for use in N-protection of bases in nucleotide synthesis, photochemical protecting groups in organic synthesis. It is used as pharmaceutical intermediate.
P Roy, Z Rajfur; D Jones; G Marriott; L Loew; K Jacobson. Local photorelease of caged thymosin beta4 in locomoting keratocytes causes cell turning. Journal of Cell Biology. 2001, 153, (5), 1035-1048.
Adam Frankel; Steven W Millward; Richard W Roberts. Encodamers: Unnatural Peptide Oligomers Encoded in RNA. Chemistry & Biology. 2003, 10, (11), 1043-1050.
Reagent for protection of amines. The group is readily cleaved photolytically: Tetrahedron Lett., 29, 65 (1988). For use in N-protection of bases in nucleotide synthesis, see: J. Org. Chem., 64, 6319 (1999). For reviews of photochemical protecting groups in organic synthesis, see: Synthesis, 1 (1980); Org. Photochem., 9, 225 (1987).
Hazard Statements: H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.