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L14167 4,5-Dimethoxy-2-nitrobenzyl chloroformate, 97%

CAS Number
42855-00-5
Synonyms
Chloroformic acid 6-nitroveratryl ester
4,5-Dimethoxy-2-nitrobenzyl chloroformate

Stock No. Size Price ($) Quantity Availability
L14167-03 1g 119.00
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4,5-Dimethoxy-2-nitrobenzyl chloroformate, 97%

MDL
MFCD00143507

Chemical Properties

Formula
C10H10ClNO6
Formula Weight
275.64
Melting point
ca 120° dec.
Storage & Sensitivity
Keep Cold. Moisture Sensitive. Light Sensitive.
Solubility
Soluble in methanol, acetone. Reacts with water.

Applications

4,5-Dimethoxy-2-nitrobenzyl chloroformate is used as a reagent for protection of amines, for use in N-protection of bases in nucleotide synthesis, photochemical protecting groups in organic synthesis. It is used as pharmaceutical intermediate.

Notes

Moisture and light sensitive. Store away from oxidizing agents, light, water/ moisture, heat, bases.

Literature References

P Roy, Z Rajfur; D Jones; G Marriott; L Loew; K Jacobson. Local photorelease of caged thymosin beta4 in locomoting keratocytes causes cell turning. Journal of Cell Biology. 2001, 153, (5), 1035-1048.

Adam Frankel; Steven W Millward; Richard W Roberts. Encodamers: Unnatural Peptide Oligomers Encoded in RNA. Chemistry & Biology. 2003, 10, (11), 1043-1050.

Reagent for protection of amines. The group is readily cleaved photolytically: Tetrahedron Lett., 29, 65 (1988). For use in N-protection of bases in nucleotide synthesis, see: J. Org. Chem., 64, 6319 (1999). For reviews of photochemical protecting groups in organic synthesis, see: Synthesis, 1 (1980); Org. Photochem., 9, 225 (1987).

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H335

Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2389168
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2915.90
TSCA
No

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